Benadryl Restless Legs Reddit, I have to constantly move from side to my back to the other side and that every 2 minutes. Then, they started making the RLS worse. In particular, anti-nausea drugs and sedating antihistamines can block the brain’s dopamine receptors, increasing the symptoms of restless legs. Benadryl is really no longer considered a good medication for anything. I’m not sure if it’s akathesia or restless legs or if there’s a difference but it only happens right after I take my meds when I’m trying to go to sleep. Antidepressants that increase serotonin and antipsychotic medications can also aggravate the condition. I mean, I wouldn't wish that on my own worst enemy. I’m wondering since it was probably caused by the Benadryl they gave me in the ER, will the restless legs eventually go away with the Benadryl getting flushed out of my body (which seems to take a while) or is this something that will just be a thing now? Id appreciate any info and help/advice Archived post. Sources below, avoid the antihistamines. Benadryl, Unisom, Zzzquil, as well as prescription Atarax, or anything including sedative antihistamines will most likely make your RLS worse. o3irv3, j5, oaoicj, waeijo, 5f, erk, 58t, 5ako, qfvtzv, qnywzg,